Joseph DeSimone Image Map
Oct 272017
 

erin_wilson_2014Congratulations to Erin Wilson, who successfully defended her dissertation on September 28th! Wilson’s research focused on the development of precisely engineered inhalable protein formulations, which non-invasively deliver therapeutic proteins for both respiratory and systemic diseases. Her dissertation, “Developing PRINT Dry Powders for Pulmonary Protein Delivery,” focused on the impact of fabrication conditions on protein stability and the influence of particle geometry on dry powder fluidization, aerosolization, and deposition. PRINT protein dry powders exhibited high delivery efficiency and deposition precision, which could improve the efficacy and safety of inhaled therapeutics.

Wilson plans to continue her research in formulation development in the pharmaceutical industry.

 October 27, 2017
Oct 252017
 

cassie_caudill_2014Congratulations to Cassie Caudill, who successfully defended her dissertation on September 28th! Caudill’s research focused on the development of microneedles, arrays of micron-scale needles that pierce the skin and facilitate the delivery of therapeutics through the skin in a minimally-invasive manner. Her dissertation, “Engineering Microneedles for the Transdermal Delivery of Therapeutics,” focused on using two technologies, PRINT and CLIP, to manufacture polymeric microneedles for drug delivery applications. Her work addresses the need for scalable and controlled fabrication of microneedles devices, which can be used to transdermally deliver a range of potential therapeutics, including small molecules, proteins, and nanoparticles.

 October 25, 2017
Oct 242017
 

Adam QCongratulations to Adam Quintanilla, who successfully defended his dissertation on September 25th! His dissertation, “Fundamentals of Particulate-Filled Polymer Composite via Continuous Liquid Interface Production,” focused on the effect of heterogenous phases (solid or liquid) within photocurable resin for the CLIP process. Quintanilla’s work used mechanical, thermal, and kinetic techniques to investigate the effect of fillers on liquid deadzone formation and thickness, the location and distribution of filler within 3D printed objects, and the potential for formulating printable rubber-toughened thermosets. This effort provides the groundwork for enabling polymer composites fabrication directly using CLIP.

Quintanilla’s career aspirations include pursuing a process engineering or project leadership/management role within a chemical engineering industry.

 October 24, 2017
Oct 232017
 

Cameron_BloomquistCongratulations to Cameron Bloomquist, who successfully defended his dissertation on September 28th! Bloomquist’s dissertation, “Continuous Liquid Interface Production of Medical Devices for Drug Delivery and Cancer Therapy,” explored how small molecule drug release can be controlled through design and formulation parameters such as device geometry, crosslink density, and polymer network composition. This work also characterized the clinical suitability of CLIP devices, including analysis of drug stability to the CLIP process and biocompatibility of the resulting part. These lessons were applied to the development of a drug-eluting implantable device for reducing the incidence of tumor recurrence following surgical resection.

In his career, Bloomquist is seeking to apply his research and leadership experience towards industry roles focused on biomaterials development and drug delivery.

 October 23, 2017
Sep 152017
 

DeSimone_Heinz_PhotoCongratulations to Professor DeSimone, who has been named the winner of the 22nd Heinz Award in the Technology, Economy, and Employment category! The honor recognizes DeSimone’s achievements and leadership in multiple fields, including green chemistry, nanomedicine, and 3D printing. “By pursuing research paths at the interface of diverse disciplines, my students, coworkers and I have developed new technologies that, over time, have influenced areas including manufacturing and medicine,” DeSimone said. “This award is a testament not just to our discoveries, but to our approach to research—bringing together people with diverse backgrounds and expertise to solve difficult scientific challenges, ultimately to create a positive impact in the world.”

Read UNC’s feature story

Read The Heinz Foundation’s features here & here

Read WRAL’s article by Rick Smith

Read The News & Observer’s article by Jane Stancill

 September 15, 2017